InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Plod3

Summary

InnateDB Protein

IDBP-204722.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Plod3

Protein Name

procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3

Synonyms

AI414586; LH3;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000004968

InnateDB Gene

IDBG-204720 (Plod3)

Protein Structure

UniProt Annotation

Function

Forms hydroxylysine residues in -Xaa-Lys-Gly- sequences in collagens. These hydroxylysines serve as sites of attachment for carbohydrate units and are essential for the stability of the intermolecular collagen cross-links.

Subcellular Localization

Rough endoplasmic reticulum membrane; Peripheral membrane protein; Lumenal side.

Disease Associations

Tissue Specificity

Highly expressed in the heart, lung, liver and testis. {ECO:0000269PubMed:10429951}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 20 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	20 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005506	iron ion binding
GO:0005515	protein binding
GO:0008475	procollagen-lysine 5-dioxygenase activity
GO:0016491	oxidoreductase activity
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0016706	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors
GO:0031418	L-ascorbic acid binding
GO:0033823	procollagen glucosyltransferase activity

Biological Process

GO:0001701	in utero embryonic development
GO:0001886	endothelial cell morphogenesis
GO:0008104	protein localization
GO:0021915	neural tube development
GO:0030199	collagen fibril organization
GO:0032870	cellular response to hormone stimulus
GO:0042311	vasodilation
GO:0048730	epidermis morphogenesis
GO:0055114	oxidation-reduction process
GO:0060425	lung morphogenesis
GO:0070831	basement membrane assembly