InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Slamf1

Summary

InnateDB Protein

IDBP-204834.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Slamf1

Protein Name

signaling lymphocytic activation molecule family member 1

Synonyms

4933415F16; AA177906; CD150; CDw150; ESTM51; IPO-3; Slam;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000015460

InnateDB Gene

IDBG-204832 (Slamf1)

Protein Structure

UniProt Annotation

Function

High-affinity self-ligand important in bidirectional T- cell to B-cell stimulation. SLAM-induced signal-transduction events in T-lymphocytes are different from those in B-cells. Two modes of SLAM signaling are likely to exist: one in which the inhibitor SH2D1A acts as a negative regulator and another in which protein-tyrosine phosphatase 2C (PTPN11)-dependent signal transduction operates.

Subcellular Localization

Cell membrane; Single-pass type I membrane protein. Note=Present on the surface of B-cells and T-cells.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	13 [view]
Protein-Protein	12 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004872	receptor activity
GO:0005515	protein binding

Biological Process

GO:0031338	regulation of vesicle fusion
GO:0046649	lymphocyte activation
GO:0050790	regulation of catalytic activity

Cellular Component

GO:0009897	external side of plasma membrane
GO:0009986	cell surface
GO:0016021	integral component of membrane
GO:0045335	phagocytic vesicle
GO:0070062	extracellular vesicular exosome