InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Scn11a

Summary

InnateDB Protein

IDBP-204848.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Scn11a

Protein Name

sodium channel, voltage-gated, type XI, alpha

Synonyms

NaN; NaT; NaV1.9; NSS2; SNS2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000065466

InnateDB Gene

IDBG-204846 (Scn11a)

Protein Structure

UniProt Annotation

Function

This protein mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which sodium ions may pass in accordance with their electrochemical gradient. It is a tetrodotoxin-resistant sodium channel isoform. Also involved, with the contribution of the receptor tyrosine kinase NTRK2, in rapid BDNF-evoked neuronal depolarization (By similarity). {ECO:0000250}.

Subcellular Localization

Membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed in the dorsal root ganglia (C-fiber neurons), spinal cord, trigeminal ganglia, testis, ovary, uterus and small intestine. {ECO:0000269PubMed:10623609}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005216	ion channel activity
GO:0005248	voltage-gated sodium channel activity
GO:0005515	protein binding

Biological Process

GO:0006811	ion transport
GO:0006814	sodium ion transport
GO:0019228	neuronal action potential
GO:0034765	regulation of ion transmembrane transport
GO:0035725	sodium ion transmembrane transport
GO:0051930	regulation of sensory perception of pain
GO:0055085	transmembrane transport
GO:0086010	membrane depolarization during action potential

Cellular Component

GO:0001518	voltage-gated sodium channel complex
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0030424	axon
GO:0044299	C-fiber
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

MGI:1345149

InterPro

IPR001696 Voltage gated sodium channel, alpha subunit
IPR003915 Polycystic kidney disease type 2 protein
IPR005821 Ion transport domain
IPR010526 Sodium ion transport-associated
IPR013122 Polycystin cation channel, PKD1/PKD2

PFAM

PF00520
PF06512
PF08016

PRINTS

PR00170
PR01433

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9R053