InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ufsp1

Summary

InnateDB Protein

IDBP-204882.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ufsp1

Protein Name

UFM1-specific peptidase 1

Synonyms

2700038N03Rik; D5Ertd655e;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000056156

InnateDB Gene

IDBG-204880 (Ufsp1)

Protein Structure

UniProt Annotation

Function

Thiol protease which recognizes and hydrolyzes the peptide bond at the C-terminal Gly of UFM1, a ubiquitin-like modifier protein bound to a number of target proteins. Does not hydrolyze SUMO1 or ISG15 ubiquitin-like proteins. {ECO:0000269PubMed:17182609}.

Subcellular Localization

Disease Associations

Tissue Specificity

Widely expressed. Expressed at higher level in brain, heart, kidney and skeletal muscle. {ECO:0000269PubMed:17182609}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0016790	thiolester hydrolase activity
GO:0071567	UFM1 hydrolase activity

Biological Process

GO:0006508

proteolysis

Cellular Component

GO:0005575	cellular_component
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

MGI:1917490

InterPro

IPR012462 Peptidase C78, ubiquitin fold modifier-specific peptidase 1/ 2

PFAM

PF07910

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9CZP0

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

70240

UniGene

Mm.124666

RefSeq

NP_081632

MGI ID

2Z84

MGI Symbol

Ufsp1

OMIM

CCDS

CCDS19764

HPRD

IMGT

EMBL

AF312033 AK012343 BC016577 BC087958

GenPept

AAH16577 AAH87958 AAK28831 BAB28174