InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Wdr48

Summary

InnateDB Protein

IDBP-204917.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Wdr48

Protein Name

WD repeat domain 48

Synonyms

8430408H12Rik; mKIAA1449; Uaf1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000042509

InnateDB Gene

IDBG-204915 (Wdr48)

Protein Structure

UniProt Annotation

Function

Regulator of deubiquitinating complexes. Acts as a strong activator of USP1 by enhancing the USP1-mediated deubiquitination of FANCD2; USP1 being almost inactive by itself. Also activates deubiquitinating activity of complexes containing USP12 and USP46, respectively. Activates deubiquitination by increasing the catalytic turnover without increasing the affinity of deubiquitinating enzymes for the substrate. May play a role in vesicular transport or membrane fusion events necessary for transport to lysosomes (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}. Lysosome {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 69 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	69 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003674	molecular_function
GO:0005515	protein binding

Biological Process

GO:0000724	double-strand break repair via homologous recombination
GO:0006974	cellular response to DNA damage stimulus
GO:0007283	spermatogenesis
GO:0007338	single fertilization
GO:0008584	male gonad development
GO:0016579	protein deubiquitination
GO:0035264	multicellular organism growth
GO:0043588	skin development
GO:0048568	embryonic organ development
GO:0048705	skeletal system morphogenesis
GO:0048872	homeostasis of number of cells
GO:0050679	positive regulation of epithelial cell proliferation
GO:0072520	seminiferous tubule development
GO:1902525	regulation of protein monoubiquitination