Mus musculus Protein: Apitd1 | |||||||||||||
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Summary | |||||||||||||
InnateDB Protein | IDBP-204935.6 | ||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||
Gene Symbol | Apitd1 | ||||||||||||
Protein Name | apoptosis-inducing, TAF9-like domain 1 | ||||||||||||
Synonyms | 2610040C18Rik; 2810407L01Rik; CENP-S; | ||||||||||||
Species | Mus musculus | ||||||||||||
Ensembl Protein | ENSMUSP00000030813 | ||||||||||||
InnateDB Gene | IDBG-204933 (Apitd1) | ||||||||||||
Protein Structure | |||||||||||||
UniProt Annotation | |||||||||||||
Function | DNA-binding component of the FA core complex involved in DNA damage repair and genome maintenance. Required for optimal chromatin association of the FA core complex. Required for efficient damage-induced monoubiquitination and focus formation of FANCD2. Stabilizes FAAD24, FANCM and APITD1/CENPS in the FA core complex. Plays a role in DNA interstrand cross-linking (ICL) repair and in recovery of replication forks stalled by topoisomerase I-DNA cleavage intermediates induced by camptothecin. Component of the heterotetrameric CENP-T-W-S-X complex that binds and supercoils DNA, and plays an important role in kinetochore assembly. Component of the APITD1/CENPS complex that is essential for the stable assembly of the outer kinetochore. Plays an important role in mitotic progression and chromosome segregation. Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation (By similarity). {ECO:0000250}. | ||||||||||||
Subcellular Localization | Nucleus {ECO:0000250}. Chromosome, centromere {ECO:0000250}. Chromosome, centromere, kinetochore {ECO:0000250}. Note=Constitutively localizes to centromeres throughout the cell cycle, and to kinetochores during mitosis. The CENPA-CAD complex is probably recruited on centromeres by the CENPA-NAC complex (By similarity). {ECO:0000250}. | ||||||||||||
Disease Associations | |||||||||||||
Tissue Specificity | |||||||||||||
Comments | |||||||||||||
Interactions | |||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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Gene Ontology | |||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Protein Structure and Domains | |||||||||||||
PDB ID | MGI:1917178 | ||||||||||||
InterPro |
IPR003162
Transcription initiation factor TAFII31 IPR007125 Histone core IPR009072 Histone-fold |
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PFAM |
PF02291
PF00125 |
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PRINTS | |||||||||||||
PIRSF | |||||||||||||
SMART | |||||||||||||
TIGRFAMs | |||||||||||||
Post-translational Modifications | |||||||||||||
Modification | |||||||||||||
Cross-References | |||||||||||||
SwissProt | Q9D084 | ||||||||||||
PhosphoSite | PhosphoSite- | ||||||||||||
TrEMBL | A6PWQ1 | ||||||||||||
UniProt Splice Variant | |||||||||||||
Entrez Gene | 69928 | ||||||||||||
UniGene | |||||||||||||
RefSeq | NP_081539 | ||||||||||||
MGI ID | |||||||||||||
MGI Symbol | Apitd1 | ||||||||||||
OMIM | |||||||||||||
CCDS | CCDS18954 | ||||||||||||
HPRD | |||||||||||||
IMGT | |||||||||||||
EMBL | AK011725 AK012995 AK013038 AL731655 BC048521 | ||||||||||||
GenPept | AAH48521 BAB27801 BAC25385 BAC25387 CAM18590 | ||||||||||||