InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Rrp8

Summary

InnateDB Protein

IDBP-204940.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Rrp8

Protein Name

ribosomal RNA processing 8, methyltransferase, homolog (yeast)

Synonyms

1500003O22Rik; 2900001K19Rik; AW538116;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000033179

InnateDB Gene

IDBG-204936 (Rrp8)

Protein Structure

UniProt Annotation

Function

Essential component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone-modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys- 9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. In the complex, RRP8 binds to H3K9me2 and probably acts as a methyltransferase. Its substrates are however unknown (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus, nucleolus {ECO:0000250}. Note=Localizes at rDNA locus. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008168	methyltransferase activity
GO:0035064	methylated histone binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0000183	chromatin silencing at rDNA
GO:0006351	transcription, DNA-templated
GO:0006364	rRNA processing
GO:0008152	metabolic process
GO:0016568	chromatin modification
GO:0032259	methylation
GO:0042149	cellular response to glucose starvation
GO:0046015	regulation of transcription by glucose
GO:0071158	positive regulation of cell cycle arrest
GO:0072332	intrinsic apoptotic signaling pathway by p53 class mediator