InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Pgd

Summary

InnateDB Protein

IDBP-204949.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Pgd

Protein Name

phosphogluconate dehydrogenase

Synonyms

0610042A05Rik; AU019875; C78335;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000081141

InnateDB Gene

IDBG-204947 (Pgd)

Protein Structure

UniProt Annotation

Function

Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH. {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.

Predicted by orthology
Total	14 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004616	phosphogluconate dehydrogenase (decarboxylating) activity
GO:0050661	NADP binding

Biological Process

GO:0006098	pentose-phosphate shunt
GO:0009051	pentose-phosphate shunt, oxidative branch
GO:0019322	pentose biosynthetic process
GO:0019521	D-gluconate metabolic process
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

MGI:97553

InterPro

IPR006113 6-phosphogluconate dehydrogenase, decarboxylating
IPR006114 6-phosphogluconate dehydrogenase, C-terminal
IPR006115 6-phosphogluconate dehydrogenase, NADP-binding
IPR008927 6-phosphogluconate dehydrogenase, C-terminal-like

PFAM

PF00393
PF03446

PRINTS

PIRSF

PIRSF000109

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9DCD0