Version 5.4
Mus musculus Protein: Gorasp1
Summary
InnateDB Protein IDBP-204962.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Gorasp1
Protein Name golgi reassembly stacking protein 1
Synonyms 5430411C10Rik; GOLPH5; GRASP65; P65;
Species Mus musculus
Ensembl Protein ENSMUSP00000035099
InnateDB Gene IDBG-204960 (Gorasp1)
Protein Structure
UniProt Annotation
Function Stacking factor involved in the postmitotic assembly of Golgi stacks from mitotic Golgi fragments. Key structural protein required for the maintenance of the Golgi apparatus integrity: its caspase-mediated cleavage is required for fragmentation of the Golgi during apoptosis. Also mediates, via its interaction with GM130, the docking of transport vesicles with the Golgi membranes (By similarity). {ECO:0000250}.
Subcellular Localization Golgi apparatus, cis-Golgi network membrane; Peripheral membrane protein; Cytoplasmic side. Note=Undergoes rapid exchange with the cytosol. {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.
Experimentally validated
Total 8 [view]
Protein-Protein 8 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 10 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0005515 protein binding
Biological Process
GO:0007030 Golgi organization
GO:0015031 protein transport
GO:0050774 negative regulation of dendrite morphogenesis
Cellular Component
GO:0005737 cytoplasm
GO:0005794 Golgi apparatus
GO:0016020 membrane
Protein Structure and Domains
PDB ID MGI:1921748
InterPro IPR001478 PDZ domain
IPR024958 GRASP55/65 PDZ-like domain
PFAM PF00595
PF13180
PF04495
PRINTS
PIRSF
SMART SM00228
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q91X51
PhosphoSite PhosphoSite-Q91X51
TrEMBL Q3TCN5
UniProt Splice Variant
Entrez Gene 74498
UniGene Mm.104789
RefSeq NP_083252
MGI ID
MGI Symbol Gorasp1
OMIM
CCDS CCDS23619
HPRD
IMGT
EMBL AK017293 AK154986 AK170627 BC012251
GenPept AAH12251 BAB30676 BAE32975 BAE41921

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca