InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Unc45b

Summary

InnateDB Protein

IDBP-205014.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Unc45b

Protein Name

unc-45 homolog B (C. elegans)

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000018989

InnateDB Gene

IDBG-205012 (Unc45b)

Protein Structure

UniProt Annotation

Function

Acts as a co-chaperone for HSP90 and is required for proper folding of the myosin motor domain. Plays a role in sarcomere formation during muscle cell development. {ECO:0000269PubMed:12356907, ECO:0000269PubMed:18326487, ECO:0000269PubMed:18478096}.

Subcellular Localization

Cytoplasm, cytosol {ECO:0000269PubMed:18478096}.

Disease Associations

Tissue Specificity

Highly expressed in adult skeletal muscle and heart. Detected at intermediate levels in lung. Highly expressed in embryonic heart. {ECO:0000269PubMed:12356907}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005488	binding
GO:0005515	protein binding
GO:0051879	Hsp90 protein binding

Biological Process

GO:0007517	muscle organ development
GO:0030154	cell differentiation
GO:0061077	chaperone-mediated protein folding

Cellular Component

GO:0005829

cytosol

Protein Structure and Domains

PDB ID

MGI:2443377

InterPro

IPR000225 Armadillo
IPR013026 Tetratricopeptide repeat-containing domain
IPR016024 Armadillo-type fold
IPR019734 Tetratricopeptide repeat
IPR024660 UNC-45/Ring assembly protein 3

PFAM

PF00514
PF13174
PF13176
PF13181
PF11701

PRINTS

PIRSF

SMART

SM00185
SM00028

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q8CGY6