InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ccr8

Summary

InnateDB Protein

IDBP-205020.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ccr8

Protein Name

chemokine (C-C motif) receptor 8

Synonyms

C-C; C-C CKR-8; CC-CKR-8; CCR-8; CKR-8; Cmkbr8; mCCR8;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000038473

InnateDB Gene

IDBG-205018 (Ccr8)

Protein Structure

UniProt Annotation

Function

Receptor for the CCL1/SCY1/TCA-3 chemokine. {ECO:0000269PubMed:9469461}.

Subcellular Localization

Cell membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Expressed in thymus. {ECO:0000269PubMed:9469461}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004930	G-protein coupled receptor activity
GO:0005515	protein binding
GO:0016493	C-C chemokine receptor activity

Biological Process

GO:0006935	chemotaxis
GO:0006955	immune response
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007204	positive regulation of cytosolic calcium ion concentration
GO:0070098	chemokine-mediated signaling pathway

Cellular Component

GO:0005886	plasma membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

MGI:1201402

InterPro

IPR000276 G protein-coupled receptor, rhodopsin-like
IPR000355 Chemokine receptor family
IPR000496 Bradykinin receptor family
IPR001277 CXC chemokine receptor 4
IPR004068 CC chemokine receptor 8
IPR017452 GPCR, rhodopsin-like, 7TM
IPR019424 7TM GPCR, olfactory receptor/chemoreceptor Srsx

PFAM

PF00001
PF10320

PRINTS

PR00237
PR00657
PR00425
PR00645
PR01530

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P56484