InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Nmnat1

Summary

InnateDB Protein

IDBP-205176.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Nmnat1

Protein Name

nicotinamide nucleotide adenylyltransferase 1

Synonyms

2610529L11Rik; 5730441G13Rik; D4Cole1e; nmnat;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000030845

InnateDB Gene

IDBG-205174 (Nmnat1)

Protein Structure

UniProt Annotation

Function

Catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP. Can also use the deamidated form; nicotinic acid mononucleotide (NaMN) as substrate with the same efficiency. Can use triazofurin monophosphate (TrMP) as substrate. Also catalyzes the reverse reaction, i.e. the pyrophosphorolytic cleavage of NAD(+). For the pyrophosphorolytic activity, prefers NAD(+) and NAAD as substrates and degrades NADH, nicotinic acid adenine dinucleotide phosphate (NHD) and nicotinamide guanine dinucleotide (NGD) less effectively. Fails to cleave phosphorylated dinucleotides NADP(+), NADPH and NAADP(+) (By similarity). Protects against axonal degeneration following mechanical or toxic insults. Delays axonal degeneration after axotomy. Results in a >10-fold increase in intact neurites 72 hours after injury. {ECO:0000250, ECO:0000269PubMed:15310905, ECO:0000269PubMed:16914673}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:16914673}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000309	nicotinamide-nucleotide adenylyltransferase activity
GO:0003824	catalytic activity
GO:0004515	nicotinate-nucleotide adenylyltransferase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016779	nucleotidyltransferase activity