InnateDB Protein
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IDBP-205251.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Pea15a
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Protein Name
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phosphoprotein enriched in astrocytes 15A
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Synonyms
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Mat1; PEA-15; Pea15; Pkcs15;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000013842
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InnateDB Gene
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IDBG-205249 (Pea15a)
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Protein Structure
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Function |
Blocks Ras-mediated inhibition of integrin activation and modulates the ERK MAP kinase cascade. Inhibits RPS6KA3 activities by retaining it in the cytoplasm. Inhibits both TNFRSF6- and TNFRSF1A-mediated CASP8 activity and apoptosis. Regulates glucose transport by controlling both the content of SLC2A1 glucose transporters on the plasma membrane and the insulin-dependent trafficking of SLC2A4 from the cell interior to the surface (By similarity). {ECO:0000250}.
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Subcellular Localization |
Cytoplasm {ECO:0000269PubMed:10926929}. Note=Associated with microtubules.
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Disease Associations |
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Tissue Specificity |
Predominantly expressed in the brain. Low levels in some peripheral organs.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 16 interaction(s) predicted by orthology.
Experimentally validated |
Total |
8
[view]
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Protein-Protein |
8
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
16 [view]
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Molecular Function |
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Biological Process |
GO:0006915
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apoptotic process
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GO:0008643
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carbohydrate transport
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GO:0035556
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intracellular signal transduction
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GO:0042981
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regulation of apoptotic process
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GO:0043278
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response to morphine
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GO:0046325
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negative regulation of glucose import
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GO:1902042
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negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
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GO:1902043
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positive regulation of extrinsic apoptotic signaling pathway via death domain receptors
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Cellular Component |
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PDB ID |
MGI:104799
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InterPro |
IPR001875
Death effector domain
IPR011029
Death-like domain
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PFAM |
PF01335
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PRINTS |
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PIRSF |
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SMART |
SM00031
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TIGRFAMs |
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Modification |
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SwissProt |
Q62048
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PhosphoSite |
PhosphoSite-Q62048
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TrEMBL |
D3Z375
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UniProt Splice Variant |
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Entrez Gene |
18611
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UniGene |
Mm.544
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RefSeq |
NP_035193
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MGI ID |
2LS7
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MGI Symbol |
Pea15a
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OMIM |
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CCDS |
CCDS15510
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HPRD |
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IMGT |
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EMBL |
AC074310
AK089070
AK153141
AK153493
AK161635
AK161977
BC038282
X86694
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GenPept |
AAH38282
BAC40734
BAE31752
BAE32041
BAE36504
BAE36662
CAA60387
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