InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Casq1

Summary

InnateDB Protein

IDBP-205266.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Casq1

Protein Name

calsequestrin 1

Synonyms

CSQ; CSQ-1; CSQ1; sCSQ;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000003554

InnateDB Gene

IDBG-205264 (Casq1)

Protein Structure

UniProt Annotation

Function

Calsequestrin is a high-capacity, moderate affinity, calcium-binding protein and thus acts as an internal calcium store in muscle. The release of calcium bound to calsequestrin through a calcium release channel triggers muscle contraction. The skeletal muscle isoform (CASQ1) binds around 80 Ca(2+) ions, while the cardiac isoform (CASQ2) binds approximately 60 Ca(2+) ions (By similarity). {ECO:0000250}.

Subcellular Localization

Sarcoplasmic reticulum lumen. Note=This isoform of calsequestrin occurs in the sarcoplasmic reticulum's terminal cisternae luminal spaces of fast skeletal muscle cells.

Disease Associations

Tissue Specificity

Skeletal muscle.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005509	calcium ion binding

Biological Process

GO:0006937	regulation of muscle contraction
GO:0007029	endoplasmic reticulum organization
GO:0007519	skeletal muscle tissue development
GO:0009408	response to heat
GO:0010033	response to organic substance
GO:0010880	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
GO:0014809	regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion
GO:0014870	response to muscle inactivity
GO:0014894	response to denervation involved in regulation of muscle adaptation
GO:0051282	regulation of sequestering of calcium ion

Cellular Component

GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005794	Golgi apparatus
GO:0014802	terminal cisterna
GO:0014804	terminal cisterna lumen
GO:0016529	sarcoplasmic reticulum
GO:0030016	myofibril
GO:0030315	T-tubule
GO:0031674	I band
GO:0033018	sarcoplasmic reticulum lumen
GO:0042383	sarcolemma
GO:0043231	intracellular membrane-bounded organelle