InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Rasl10b

Summary

InnateDB Protein

IDBP-205325.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Rasl10b

Protein Name

RAS-like, family 10, member B

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000021022

InnateDB Gene

IDBG-205323 (Rasl10b)

Protein Structure

UniProt Annotation

Function

May facilitate the release of atrial natriuretic peptide by cardiomyocytes and hence play a role in the regulation of arterial pressure. {ECO:0000269PubMed:17984325}.

Subcellular Localization

Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}.

Disease Associations

Tissue Specificity

Expressed in heart and brain. In the brain, expression restricted to neurons of the cortex, hippocampus and cerebellum. Sparse expression in the brainstem and almost absent in the hypothalamic region. In the heart, expressed in cardiomyocytes. Not detected in interstitial tissue or vascular cells. {ECO:0000269PubMed:17984325}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0005525	GTP binding

Biological Process

GO:0003050	regulation of systemic arterial blood pressure by atrial natriuretic peptide
GO:0006184	GTP catabolic process
GO:0007165	signal transduction
GO:0007264	small GTPase mediated signal transduction
GO:0015031	protein transport
GO:0090277	positive regulation of peptide hormone secretion

Cellular Component

GO:0005575	cellular_component
GO:0005622	intracellular
GO:0005886	plasma membrane
GO:0016020	membrane

Protein Structure and Domains

PDB ID

MGI:2685575

InterPro

IPR001806 Small GTPase superfamily
IPR003579 Small GTPase superfamily, Rab type
IPR005225 Small GTP-binding protein domain
IPR013684 Mitochondrial Rho-like
IPR020849 Small GTPase superfamily, Ras type
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00071
PF08477

PRINTS

PR00449

PIRSF

SMART

SM00175
SM00173

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt