Version 5.4
Mus musculus Protein: Igsf8
Summary
InnateDB Protein IDBP-205338.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Igsf8
Protein Name immunoglobulin superfamily, member 8
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000041232
InnateDB Gene IDBG-205334 (Igsf8)
Protein Structure
UniProt Annotation
Function May play a key role in diverse functions ascribed to CD81 and CD9 such as oocytes fertilization or hepatitis C virus function. May regulate proliferation and differentiation of keratinocytes. May be a negative regulator of cell motility: suppresses T-cell mobility coordinately with CD81, associates with CD82 to suppress prostate cancer cell migration, regulates epidermoid cell reaggregation and motility on laminin-5 with CD9 and CD81 as key linkers. May also play a role on integrin- dependent morphology and motility functions. May participate in the regulation of neurite outgrowth and maintenance of the neural network in the adult brain. {ECO:0000269PubMed:11673522, ECO:0000269PubMed:16203089}.
Subcellular Localization Cell membrane {ECO:0000269PubMed:21609323}; Single-pass membrane protein {ECO:0000269PubMed:21609323}.
Disease Associations
Tissue Specificity Expressed in lymphocytes as well as in many tissues with higher expression in brain. Detected in all regions of the brain with weak expression in the pituitary. Expressed selectively by neurons but not by glial cells. {ECO:0000269PubMed:16203089}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 7 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0008150 biological_process
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID MGI:2154090
InterPro IPR003599 Immunoglobulin subtype
IPR007110 Immunoglobulin-like domain
IPR013106 Immunoglobulin V-set domain
PFAM PF07686
PRINTS
PIRSF
SMART SM00409
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8R366
PhosphoSite PhosphoSite-Q8R366
TrEMBL G3UYZ1
UniProt Splice Variant
Entrez Gene 140559
UniGene Mm.487654
RefSeq NP_536344
MGI ID
MGI Symbol Igsf8
OMIM
CCDS CCDS15511
HPRD
IMGT
EMBL AC087061 AF411055 AF439263 AK146104 AK146221 AK168363 BC026464 BC026633 BC048387
GenPept AAH26464 AAH26633 AAH48387 AAL02217 AAN63626 BAE26904 BAE26989 BAE40298

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca