InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Atp1a2

Summary

InnateDB Protein

IDBP-205356.5

Last Modified

2012-02-14 [Report errors or provide feedback]

Gene Symbol

Atp1a2

Protein Name

ATPase, Na+/K+ transporting, alpha 2 polypeptide

Synonyms

Atpa-3; AW060654; mKIAA0778;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000095072

InnateDB Gene

IDBG-205352 (Atp1a2)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0005391	sodium:potassium-exchanging ATPase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0015077	monovalent inorganic cation transmembrane transporter activity
GO:0016820	hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances
GO:0019829	cation-transporting ATPase activity
GO:0046872	metal ion binding

Biological Process

GO:0001504	neurotransmitter uptake
GO:0002026	regulation of the force of heart contraction
GO:0002087	regulation of respiratory gaseous exchange by neurological system process
GO:0006754	ATP biosynthetic process
GO:0006812	cation transport
GO:0006813	potassium ion transport
GO:0006937	regulation of muscle contraction
GO:0006940	regulation of smooth muscle contraction
GO:0006942	regulation of striated muscle contraction
GO:0008217	regulation of blood pressure
GO:0008344	adult locomotory behavior
GO:0008542	visual learning
GO:0015672	monovalent inorganic cation transport
GO:0015991	ATP hydrolysis coupled proton transport
GO:0019229	regulation of vasoconstriction
GO:0035094	response to nicotine
GO:0035725	sodium ion transmembrane transport
GO:0040011	locomotion
GO:0045822	negative regulation of heart contraction
GO:0045988	negative regulation of striated muscle contraction
GO:0051481	negative regulation of cytosolic calcium ion concentration
GO:0071260	cellular response to mechanical stimulus
GO:0086004	regulation of cardiac muscle cell contraction

Cellular Component

GO:0005768	endosome
GO:0005890	sodium:potassium-exchanging ATPase complex
GO:0005901	caveola
GO:0016021	integral component of membrane
GO:0030315	T-tubule
GO:0042383	sarcolemma
GO:0043197	dendritic spine
GO:0045202	synapse

Protein Structure and Domains

PDB ID

MGI:88106

InterPro

IPR001757 Cation-transporting P-type ATPase
IPR004014 Cation-transporting P-type ATPase, N-terminal
IPR005775 Sodium/potassium-transporting P-type ATPase, subfamily IIC
IPR006068 Cation-transporting P-type ATPase, C-terminal
IPR008250 P-type ATPase, A domain
IPR023214 HAD-like domain
IPR023299 P-type ATPase, cytoplasmic domain N

PFAM

PF00690
PF00689
PF00122
PF00702
PF08282
PF13419

PRINTS

PR00119
PR00120

PIRSF

SMART

SM00831

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite

PhosphoSite-

TrEMBL

D3YYN7

UniProt Splice Variant

Entrez Gene

98660

UniGene

Mm.487976

RefSeq

MGI ID

MGI Symbol

Atp1a2

OMIM

CCDS

HPRD

IMGT

EMBL

AC087061

GenPept