InnateDB Protein
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IDBP-20537.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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PPP2R5C
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Protein Name
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protein phosphatase 2, regulatory subunit B', gamma
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Synonyms
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B56G; PR61G;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000329009
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InnateDB Gene
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IDBG-20535 (PPP2R5C)
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Protein Structure
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Function |
The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. The PP2A-PPP2R5C holoenzyme may specifically dephosphorylate and activate TP53 and play a role in DNA damage- induced inhibition of cell proliferation. PP2A-PPP2R5C may also regulate the ERK signaling pathway through ERK dephosphorylation. {ECO:0000269PubMed:16456541, ECO:0000269PubMed:17245430}.
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Subcellular Localization |
Nucleus. Chromosome, centromere.
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Disease Associations |
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Tissue Specificity |
Highest levels in heart, skeletal muscle and brain. Lower levels in pancreas, kidney, lung and placenta. Very low levels in liver.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 44 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated |
Total |
44
[view]
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Protein-Protein |
44
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
2 [view]
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Molecular Function |
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Biological Process |
GO:0006977
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DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
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GO:0007165
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signal transduction
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GO:0008285
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negative regulation of cell proliferation
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GO:0042771
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intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
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GO:0043161
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proteasome-mediated ubiquitin-dependent protein catabolic process
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GO:0050790
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regulation of catalytic activity
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Cellular Component |
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PDB ID |
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InterPro |
IPR002554
Protein phosphatase 2A, regulatory B subunit, B56
IPR016024
Armadillo-type fold
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PFAM |
PF01603
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PRINTS |
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PIRSF |
PIRSF028043
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q13362
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PhosphoSite |
PhosphoSite-Q13362
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
5527
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UniGene |
Hs.733086
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RefSeq |
NP_001155198
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HUGO |
HGNC:9311
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OMIM |
601645
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CCDS |
CCDS53911
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HPRD |
03385
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IMGT |
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EMBL |
AB451341
AK131391
AK302470
AL118558
AL137779
CH471061
D26445
L42375
U37352
Z69030
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GenPept |
AAC37603
AAC50387
BAA05465
BAD18542
BAG63760
BAG70155
CAA93154
EAW81756
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