Version 5.4
Mus musculus Protein: Anapc1
Summary
InnateDB Protein IDBP-205384.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Anapc1
Protein Name anaphase promoting complex subunit 1
Synonyms 2610021O03Rik; AI047775; AI853536; Apc1; AW547281; Mcpr; tsg24;
Species Mus musculus
Ensembl Protein ENSMUSP00000014499
InnateDB Gene IDBG-205382 (Anapc1)
Protein Structure
UniProt Annotation
Function Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (By similarity). {ECO:0000250}.
Subcellular Localization
Disease Associations
Tissue Specificity Abundantly expressed in proliferating fibroblasts, juvenile testis, adult brain and epididymis.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
They are also associated with 40 interaction(s) predicted by orthology.
Experimentally validated
Total 16 [view]
Protein-Protein 16 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 40 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0007067 mitotic nuclear division
GO:0070979 protein K11-linked ubiquitination
Cellular Component
GO:0005634 nucleus
GO:0005680 anaphase-promoting complex
Protein Structure and Domains
PDB ID MGI:103097
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P53995
PhosphoSite PhosphoSite-P53995
TrEMBL Q3UE43
UniProt Splice Variant
Entrez Gene 17222
UniGene Mm.449185
RefSeq NP_032595
MGI ID
MGI Symbol Anapc1
OMIM
CCDS CCDS16715
HPRD
IMGT
EMBL AK052404 AK077847 AK149762 AK164804 AL928910 BC139002 CH466519 X80169
GenPept AAI39003 BAC34976 BAC37032 BAE29068 BAE37927 CAA56450 CAM25161 EDL28216

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca