InnateDB Protein
|
IDBP-205435.6
|
Last Modified
|
2014-10-13 [Report errors or provide feedback]
|
Gene Symbol
|
Cck
|
Protein Name
|
cholecystokinin
|
Synonyms
|
|
Species
|
Mus musculus
|
Ensembl Protein
|
ENSMUSP00000035120
|
InnateDB Gene
|
IDBG-205433 (Cck)
|
Protein Structure
|
|
Function |
This peptide hormone induces gall bladder contraction and the release of pancreatic enzymes in the gut. Its function in the brain is not clear. Binding to CCK-A receptors stimulates amylase release from the pancreas, binding to CCK-B receptors stimulates gastric acid secretion.
|
Subcellular Localization |
Secreted.
|
Disease Associations |
|
Tissue Specificity |
|
Comments |
|
Number of Interactions
|
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
|
Predicted by orthology |
Total |
3 [view]
|
|
|
Molecular Function |
|
Biological Process |
GO:0001662
|
behavioral fear response
|
GO:0001764
|
neuron migration
|
GO:0001836
|
release of cytochrome c from mitochondria
|
GO:0006915
|
apoptotic process
|
GO:0006919
|
activation of cysteine-type endopeptidase activity involved in apoptotic process
|
GO:0007205
|
protein kinase C-activating G-protein coupled receptor signaling pathway
|
GO:0007409
|
axonogenesis
|
GO:0008284
|
positive regulation of cell proliferation
|
GO:0032099
|
negative regulation of appetite
|
GO:0032461
|
positive regulation of protein oligomerization
|
GO:0042755
|
eating behavior
|
GO:0043065
|
positive regulation of apoptotic process
|
GO:0050731
|
positive regulation of peptidyl-tyrosine phosphorylation
|
GO:0051901
|
positive regulation of mitochondrial depolarization
|
GO:0051930
|
regulation of sensory perception of pain
|
|
Cellular Component |
|
PDB ID |
MGI:88297
|
InterPro |
IPR001651
Gastrin/cholecystokinin peptide hormone
|
PFAM |
PF00918
|
PRINTS |
|
PIRSF |
|
SMART |
SM00029
|
TIGRFAMs |
|
Modification |
|
SwissProt |
P09240
|
PhosphoSite |
PhosphoSite-
|
TrEMBL |
|
UniProt Splice Variant |
|
Entrez Gene |
12424
|
UniGene |
|
RefSeq |
NP_112438
|
MGI ID |
|
MGI Symbol |
Cck
|
OMIM |
|
CCDS |
CCDS23631
|
HPRD |
|
IMGT |
|
EMBL |
AK002677
M11739
X59521
X59522
|
GenPept |
AAA37382
BAB22279
CAB94216
|
|
|