InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Cyb5r2

Summary

InnateDB Protein

IDBP-205457.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cyb5r2

Protein Name

cytochrome b5 reductase 2

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000050061

InnateDB Gene

IDBG-205455 (Cyb5r2)

Protein Structure

UniProt Annotation

Function

NADH-cytochrome b5 reductases are involved in desaturation and elongation of fatty acids, cholesterol biosynthesis, drug metabolism, and, in erythrocyte, methemoglobin reduction. Responsible for NADH-dependent lucigenin chemiluminescence in spermatozoa by reducing both lucigenin and 2- [4-iodophenyl]-3-[4-nitrophenyl]-5-[2,4-disulfophenyl]-2H tetrazolium monosodium salt (WST-1) (By similarity). {ECO:0000250}.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004128	cytochrome-b5 reductase activity, acting on NAD(P)H
GO:0016491	oxidoreductase activity

Biological Process

GO:0016126	sterol biosynthetic process
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005634	nucleus
GO:0005739	mitochondrion
GO:0016020	membrane

Protein Structure and Domains

PDB ID

MGI:2444415

InterPro

IPR001433 Oxidoreductase FAD/NAD(P)-binding
IPR001709 Flavoprotein pyridine nucleotide cytochrome reductase
IPR001834 NADH:cytochrome b5 reductase (CBR)
IPR008333 Oxidoreductase, FAD-binding domain
IPR017938 Riboflavin synthase-like beta-barrel

PFAM

PF00175
PF00970

PRINTS

PR00371
PR00406

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q3KNK3