InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Zc3h8

Summary

InnateDB Protein

IDBP-205610.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Zc3h8

Protein Name

zinc finger CCCH type containing 8

Synonyms

AU020882; E130108N08Rik; Fliz1; Zc3hdc8;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000028866

InnateDB Gene

IDBG-205606 (Zc3h8)

Protein Structure

UniProt Annotation

Function

Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III. Acts as a transcriptional repressor of the GATA3 promoter. Induces thymocyte apoptosis when overexpressed, which may indicate a role in regulation of thymocyte homeostasis (By similarity). Sequence- specific DNA-binding factor that binds to the 5'-AGGTCTC-3' sequence within the negative cis-acting element intronic regulatory region (IRR) of the GATA3 gene. {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:11318609}. Note=Colocalizes with coilin in subnuclear cajal and histone locus bodies. Translocates in the LEC complex to cajal and histone locus bodies at snRNA genes in a ICE1-dependent manner. Associates to transcriptionally active chromatin at snRNA genes (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Highly expressed in heart, muscle, testis, kidney, brain, liver, lung and spleen. {ECO:0000269PubMed:11318609}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003723	RNA binding
GO:0043565	sequence-specific DNA binding
GO:0044822	poly(A) RNA binding
GO:0046872	metal ion binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006915	apoptotic process
GO:0033085	negative regulation of T cell differentiation in thymus
GO:0043029	T cell homeostasis
GO:0045892	negative regulation of transcription, DNA-templated
GO:0046677	response to antibiotic
GO:0070245	positive regulation of thymocyte apoptotic process