Version 5.4
| Mus musculus Protein: Dusp23 | |||||||||
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| Summary | |||||||||
| InnateDB Protein | IDBP-205658.6 | ||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||
| Gene Symbol | Dusp23 | ||||||||
| Protein Name | dual specificity phosphatase 23 | ||||||||
| Synonyms | 1300005N15Rik; LDP-3; | ||||||||
| Species | Mus musculus | ||||||||
| Ensembl Protein | ENSMUSP00000027826 | ||||||||
| InnateDB Gene | IDBG-205656 (Dusp23) | ||||||||
| Protein Structure |
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| UniProt Annotation | |||||||||
| Function | Protein phosphatase that mediates dephosphorylation of proteins phosphorylated on Tyr and Ser/Thr residues. In vitro, it can dephosphorylate p44-ERK1 (MAPK3) but not p54 SAPK-beta (MAPK10) in vitro. Able to enhance activation of JNK and p38 (MAPK14). {ECO:0000269PubMed:15281913}. | ||||||||
| Subcellular Localization | Cytoplasm, cytosol {ECO:0000250}. Nucleus {ECO:0000250}. Note=Mainly cytosolic. Weakly nuclear (By similarity). {ECO:0000250}. | ||||||||
| Disease Associations | |||||||||
| Tissue Specificity | Widely expressed. {ECO:0000269PubMed:15281913}. | ||||||||
| Comments | |||||||||
| Interactions | |||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 22 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Protein Structure and Domains | |||||||||
| PDB ID | MGI:1915690 | ||||||||
| InterPro |
IPR000242
Protein-tyrosine phosphatase, receptor/non-receptor type IPR000340 Dual specificity phosphatase, catalytic domain IPR000387 Protein-tyrosine/Dual specificity phosphatase IPR003595 Protein-tyrosine phosphatase, catalytic IPR020422 Dual specificity phosphatase, subgroup, catalytic domain IPR029021 Protein-tyrosine phosphatase-like |
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| PFAM |
PF00102
PF00782 |
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| PRINTS |
PR00700
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| PIRSF | |||||||||
| SMART |
SM00194
SM00404 SM00195 |
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| TIGRFAMs | |||||||||
| Post-translational Modifications | |||||||||
| Modification | |||||||||
| Cross-References | |||||||||
| SwissProt | Q6NT99 | ||||||||
| PhosphoSite | PhosphoSite- | ||||||||
| TrEMBL | |||||||||
| UniProt Splice Variant | |||||||||
| Entrez Gene | 68440 | ||||||||
| UniGene | Mm.33024 | ||||||||
| RefSeq | NP_081001 | ||||||||
| MGI ID | |||||||||
| MGI Symbol | Dusp23 | ||||||||
| OMIM | |||||||||
| CCDS | CCDS15518 | ||||||||
| HPRD | |||||||||
| IMGT | |||||||||
| EMBL | AB183013 AK004912 BC069187 | ||||||||
| GenPept | AAH69187 BAB23663 BAD26711 | ||||||||