InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Eno1

Summary

InnateDB Protein

IDBP-205701.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Eno1

Protein Name

enolase 1, alpha non-neuron

Synonyms

0610008I15; AL022784; Eno-1; MBP-1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000079727

InnateDB Gene

IDBG-205699 (Eno1)

Protein Structure

UniProt Annotation

Function

Multifunctional enzyme that, as well as its role in glycolysis, plays a part in various processes such as growth control, hypoxia tolerance and allergic responses (By similarity). May also function in the intravascular and pericellular fibrinolytic system due to its ability to serve as a receptor and activator of plasminogen on the cell surface of several cell-types such as leukocytes and neurons. Stimulates immunoglobulin production (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Cell membrane {ECO:0000250}. Note=Can translocate to the plasma membrane in either the homodimeric (alpha/alpha) or heterodimeric (alpha/gamma) form (By similarity). ENO1 is localized to the M- band. {ECO:0000250, ECO:0000269PubMed:11229603}.

Disease Associations

Tissue Specificity

The alpha/alpha homodimer is expressed in embryo and in most adult tissues. The alpha/beta heterodimer and the beta/beta homodimer are found in striated muscle, and the alpha/gamma heterodimer and the gamma/gamma homodimer in neurons. In striated muscle, expression of ENO1 appears to be independent of fiber type. {ECO:0000269PubMed:11229603}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.

Experimentally validated
Total	18 [view]
Protein-Protein	18 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000287	magnesium ion binding
GO:0004634	phosphopyruvate hydratase activity

Biological Process

GO:0006096

glycolytic process

Cellular Component

GO:0000015	phosphopyruvate hydratase complex
GO:0005886	plasma membrane

Protein Structure and Domains

PDB ID

MGI:95393

InterPro

IPR000941 Enolase
IPR020810 Enolase, C-terminal
IPR020811 Enolase, N-terminal
IPR029017 Enolase N-terminal domain-like
IPR029065 Enolase C-terminal domain-like

PFAM

PF00113
PF03952

PRINTS

PR00148

PIRSF

PIRSF001400

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt