InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Polr1b

Summary

InnateDB Protein

IDBP-205732.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Polr1b

Protein Name

polymerase (RNA) I polypeptide B

Synonyms

128kDa; D630020H17Rik; RPA116; RPA135; RPA2; Rpo1-2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000099494

InnateDB Gene

IDBG-205730 (Polr1b)

Protein Structure

UniProt Annotation

Function

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Second largest core component of RNA polymerase I which synthesizes ribosomal RNA precursors. Proposed to contribute to the polymerase catalytic activity and forms the polymerase active center together with the largest subunit. Pol I is composed of mobile elements and RPA2 is part of the core element with the central large cleft and probably a clamp element that moves to open and close the cleft (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus, nucleolus {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 34 interaction(s) predicted by orthology.

Experimentally validated
Total	9 [view]
Protein-Protein	9 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	34 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001054	RNA polymerase I activity
GO:0003677	DNA binding
GO:0003899	DNA-directed RNA polymerase activity
GO:0005515	protein binding
GO:0032549	ribonucleoside binding
GO:0046872	metal ion binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006360	transcription from RNA polymerase I promoter
GO:0007566	embryo implantation
GO:0009303	rRNA transcription
GO:0017126	nucleologenesis

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005730	nucleolus
GO:0005736	DNA-directed RNA polymerase I complex
GO:0005737	cytoplasm

Protein Structure and Domains

PDB ID

MGI:108014

InterPro

IPR007120 DNA-directed RNA polymerase, subunit 2, domain 6
IPR007641 RNA polymerase Rpb2, domain 7
IPR007642 RNA polymerase Rpb2, domain 2
IPR007644 RNA polymerase, beta subunit, protrusion
IPR007645 RNA polymerase Rpb2, domain 3
IPR009674 RNA polymerase I, Rpa2 specific

PFAM

PF00562
PF04560
PF04561
PF04563
PF04565
PF06883

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P70700

PhosphoSite