InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: HOOK3

Summary

InnateDB Protein

IDBP-20578.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

HOOK3

Protein Name

hook homolog 3 (Drosophila)

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000305699

InnateDB Gene

IDBG-20576 (HOOK3)

Protein Structure

UniProt Annotation

Function

Probably serves as a target for the spiC protein from Salmonella typhimurium, which inactivates it, leading to a strong alteration in cellular trafficking (By similarity). Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). May regulate clearance of endocytosed receptors such as MSR1. Participates in defining the architecture and localization of the Golgi complex. {ECO:0000250, ECO:0000269PubMed:11238449, ECO:0000269PubMed:17237231, ECO:0000269PubMed:18799622}.

Subcellular Localization

Cytoplasm, cytoskeleton {ECO:0000269PubMed:11238449}. Golgi apparatus {ECO:0000269PubMed:11238449}. Note=Enriched at the cis-face of the Golgi complex. Localizes to microtubule asters in prophase. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	15 [view]
Protein-Protein	14 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008017	microtubule binding
GO:0042802	identical protein binding

Biological Process

GO:0007032	endosome organization
GO:0007040	lysosome organization
GO:0008333	endosome to lysosome transport
GO:0015031	protein transport
GO:0016192	vesicle-mediated transport
GO:0022027	interkinetic nuclear migration
GO:0031122	cytoplasmic microtubule organization
GO:0034454	microtubule anchoring at centrosome
GO:0045022	early endosome to late endosome transport
GO:0050768	negative regulation of neurogenesis
GO:0051645	Golgi localization
GO:0071539	protein localization to centrosome
GO:0097150	neuronal stem cell maintenance

Cellular Component

GO:0000242	pericentriolar material
GO:0005737	cytoplasm
GO:0005794	Golgi apparatus
GO:0005801	cis-Golgi network
GO:0005813	centrosome
GO:0005815	microtubule organizing center
GO:0005874	microtubule
GO:0016020	membrane
GO:0030897	HOPS complex
GO:0034451	centriolar satellite
GO:0070695	FHF complex