InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Fcer1a

Summary

InnateDB Protein

IDBP-205784.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Fcer1a

Protein Name

Fc receptor, IgE, high affinity I, alpha polypeptide

Synonyms

Fce1a; fcepsilonri; FcERI; Fcr-5;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000056882

InnateDB Gene

IDBG-205782 (Fcer1a)

Protein Structure

UniProt Annotation

Function

Binds to the Fc region of immunoglobulins epsilon. High affinity receptor. Responsible for initiating the allergic response. Binding of allergen to receptor-bound IgE leads to cell activation and the release of mediators (such as histamine) responsible for the manifestations of allergy. The same receptor also induces the secretion of important lymphokines.

Subcellular Localization

Cell membrane; Single-pass type I membrane protein.

Disease Associations

Tissue Specificity

Expressed in bone marrow mast cells, as well as in the pineal gland at night. {ECO:0000269PubMed:17728245}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	1 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0019767	IgE receptor activity
GO:0019863	IgE binding

Biological Process

GO:0000187	activation of MAPK activity
GO:0001812	positive regulation of type I hypersensitivity
GO:0001820	serotonin secretion
GO:0007165	signal transduction
GO:0007166	cell surface receptor signaling pathway
GO:0007257	activation of JUN kinase activity
GO:0019370	leukotriene biosynthetic process
GO:0038095	Fc-epsilon receptor signaling pathway
GO:0043306	positive regulation of mast cell degranulation
GO:0045401	positive regulation of interleukin-3 biosynthetic process
GO:0045425	positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process
GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation
GO:0050850	positive regulation of calcium-mediated signaling