InnateDB Protein
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IDBP-205855.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Errfi1
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Protein Name
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ERBB receptor feedback inhibitor 1
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Synonyms
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1300002F13Rik; AI788755; Mig-6; Mig6; RALT;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000073285
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InnateDB Gene
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IDBG-205853 (Errfi1)
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Protein Structure
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Function |
Negative regulator of EGFR signaling in skin morphogenesis. Acts as a negative regulator for several EGFR family members, including ERBB2, ERBB3 and ERBB4. Inhibits EGFR catalytic activity by interfering with its dimerization. Inhibits autophosphorylation of EGFR, ERBB2 and ERBB4. Important for normal keratinocyte proliferation and differentiation. Plays a role in modulating the response to steroid hormones in the uterus. Required for normal response to progesterone in the uterus and for fertility. Mediates epithelial estrogen responses in the uterus by regulating ESR1 levels and activation. Important for regulation of endometrium cell proliferation. Important for normal prenatal and perinatal lung development. {ECO:0000269PubMed:16648858, ECO:0000269PubMed:19439667, ECO:0000269PubMed:19683494, ECO:0000269PubMed:19710174, ECO:0000269PubMed:20018910}.
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Subcellular Localization |
Cytoplasm {ECO:0000269PubMed:16648858}. Cell membrane {ECO:0000269PubMed:16648858}; Peripheral membrane protein {ECO:0000269PubMed:16648858}; Cytoplasmic side {ECO:0000269PubMed:16648858}. Nucleus {ECO:0000305PubMed:16648858}. Note=Associated with the plasma membrane of basal skin keratinocytes. Translocates into the nucleus of differentiating suprabasal keratinocytes.
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Disease Associations |
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Tissue Specificity |
Detected in lung, in airway epithelial cells and alveolar type 2 cells (at protein level). Detected in uterus stroma, luminal epithelium and glandular epithelium. {ECO:0000269PubMed:16648858, ECO:0000269PubMed:19710174}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.
Experimentally validated |
Total |
4
[view]
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Protein-Protein |
4
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
10 [view]
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Molecular Function |
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Biological Process |
GO:0007175
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negative regulation of epidermal growth factor-activated receptor activity
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GO:0031953
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negative regulation of protein autophosphorylation
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GO:0042059
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negative regulation of epidermal growth factor receptor signaling pathway
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GO:0043589
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skin morphogenesis
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GO:0045616
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regulation of keratinocyte differentiation
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GO:0048286
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lung alveolus development
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GO:0050732
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negative regulation of peptidyl-tyrosine phosphorylation
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GO:0060426
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lung vasculature development
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GO:0060428
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lung epithelium development
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Cellular Component |
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PDB ID |
MGI:1921405
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InterPro |
IPR015116
Cdc42 binding domain like
IPR021619
EGFR receptor inhibitor Mig-6
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PFAM |
PF09027
PF11555
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q99JZ7
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PhosphoSite |
PhosphoSite-Q99JZ7
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TrEMBL |
Q3TK48
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UniProt Splice Variant |
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Entrez Gene |
74155
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UniGene |
Mm.475529
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RefSeq |
XP_006537151
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MGI ID |
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MGI Symbol |
Errfi1
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OMIM |
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CCDS |
CCDS18974
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HPRD |
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IMGT |
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EMBL |
AK166791
AK167156
BC005546
BC057646
CH466594
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GenPept |
AAH05546
AAH57646
BAE39021
BAE39297
EDL14895
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