InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Tub

Summary

InnateDB Protein

IDBP-206028.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Tub

Protein Name

tubby candidate gene

Synonyms

rd5; tub;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000033341

InnateDB Gene

IDBG-206024 (Tub)

Protein Structure

UniProt Annotation

Function

Functions in signal transduction from heterotrimeric G protein-coupled receptors. Binds to membranes containing phosphatidylinositol 4,5-bisphosphate. Can bind DNA (in vitro). May contribute to the regulation of transcription in the nucleus. Could be involved in the hypothalamic regulation of body weight. Contribute to stimulation of phagocytosis of apoptotic retinal pigment epithelium (RPE) cells and macrophages (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm. Nucleus. Secreted. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Note=Binds phospholipid and is anchored to the plasma membrane through binding phosphatidylinositol 4,5-bisphosphate. Is released upon activation of phospholipase C. Translocates from the plasma membrane to the nucleus upon activation of guanine nucleotide- binding protein G(q) subunit alpha. Does not have a cleavable signal peptide and is secreted by a non-conventional pathway.

Disease Associations

Note=Defects in Tub are the cause of maturity-onset obesity, insulin resistance and sensory deficits.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008020	G-protein coupled photoreceptor activity
GO:0032403	protein complex binding

Biological Process

GO:0006909	phagocytosis
GO:0007602	phototransduction
GO:0007605	sensory perception of sound
GO:0009584	detection of visible light
GO:0009725	response to hormone
GO:0044259	multicellular organismal macromolecule metabolic process
GO:0050766	positive regulation of phagocytosis
GO:0060041	retina development in camera-type eye