Version 5.4
Mus musculus Protein: Kif15
Summary
InnateDB Protein IDBP-206059.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Kif15
Protein Name kinesin family member 15
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000035490
InnateDB Gene IDBG-206057 (Kif15)
Protein Structure
UniProt Annotation
Function Plus-end directed kinesin-like motor enzyme involved in mitotic spindle assembly. {ECO:0000250}.
Subcellular Localization Cytoplasm {ECO:0000250}. Cytoplasm, cytoskeleton, spindle {ECO:0000250}. Note=Detected during the interphase in the cytoplasm as finely punctuate pattern and irregularly shaped dots. Localizes at the spindle poles and microtubules prior to anaphase. Localizes at the central spindle at anaphase. Localizes at the sites of invaginating cell membranes, a position that corresponds to the location of the contractile actomyosin ring of dividing cells. Colocalizes with actin in interphase. Colocalizes in dendrites and in growth cone of axons with microtubules. Colocalizes with TPX2 in mitosis (By similarity). {ECO:0000250}.
Disease Associations
Tissue Specificity Expressed in brain (neurons in the external germinal layer of the cerebellum and in ventricular zones) (at protein level). Expressed in spleen and testis. {ECO:0000269PubMed:14618103, ECO:0000269PubMed:9275178}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 8 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003777 microtubule motor activity
GO:0005524 ATP binding
GO:0008017 microtubule binding
Biological Process
GO:0007018 microtubule-based movement
GO:0008152 metabolic process
Cellular Component
GO:0005737 cytoplasm
GO:0005819 spindle
GO:0005871 kinesin complex
GO:0005874 microtubule
GO:0016020 membrane
Protein Structure and Domains
PDB ID MGI:1098258
InterPro IPR001752 Kinesin, motor domain
IPR027417 P-loop containing nucleoside triphosphate hydrolase
PFAM PF00225
PRINTS PR00380
PIRSF
SMART SM00129
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q6P9L6
PhosphoSite PhosphoSite-Q6P9L6
TrEMBL
UniProt Splice Variant
Entrez Gene 209737
UniGene Mm.278920
RefSeq NP_034750
MGI ID
MGI Symbol Kif15
OMIM
CCDS CCDS23651
HPRD
IMGT
EMBL AB001432 AJ560623 BC060710
GenPept AAH60710 BAA22392 CAD90258

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca