Version 5.4
Homo sapiens Protein: CATSPERD
Summary
InnateDB Protein IDBP-20606.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CATSPERD
Protein Name transmembrane protein 146
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000371037
InnateDB Gene IDBG-20604 (CATSPERD)
Protein Structure
UniProt Annotation
Function Auxiliary component of the CatSper complex, a complex involved in sperm cell hyperactivation. Sperm cell hyperactivation is needed for sperm motility which is essential late in the preparation of sperm for fertilization. Required for CATSPER1 stability before intraflagellar transport and/or incorporation of the CatSper complex channel into the flagellar membrane (By similarity). {ECO:0000250}.
Subcellular Localization Cell projection, cilium, flagellum membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Note=Specifically located in the principal piece of sperm tail. {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0007275 multicellular organismal development
GO:0007283 spermatogenesis
GO:0007338 single fertilization
GO:0030317 sperm motility
GO:0032504 multicellular organism reproduction
GO:0035036 sperm-egg recognition
GO:0048240 sperm capacitation
Cellular Component
GO:0005886 plasma membrane
GO:0036128 CatSper complex
GO:0097228 sperm principal piece
Protein Structure and Domains
PDB ID
InterPro IPR017986 WD40-repeat-containing domain
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q86XM0
PhosphoSite PhosphoSite-Q86XM0
TrEMBL
UniProt Splice Variant
Entrez Gene 257062
UniGene
RefSeq NP_689997
HUGO HGNC:28598
OMIM
CCDS CCDS12149
HPRD 17541
IMGT
EMBL AC011499 AK128088 BC043005
GenPept AAH43005

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

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Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca