InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ifi202b

Summary

InnateDB Protein

IDBP-206065.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ifi202b

Protein Name

interferon activated gene 202B

Synonyms

Ifbip-1; Ifi202; Ifi202a; p202;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000000266

InnateDB Gene

IDBG-206063 (Ifi202b)

Protein Structure

UniProt Annotation

Function

Inhibits the transcriptional activity of several transcription factors, including NF-kappa-B p50 and p65, FOS, JUN, E2F1, E2F4, MYOD1 and myogenin. Has anti-apoptotic effects due to inhibition of the transcriptional activity of p53. Binds dsDNA in the cytosol. Is involved in innate immune response and has anti- inflammatory activity. Inhibits caspase activation in response to cytosolic DNA and inhibits the activation of the AIM2 inflammasome, probably by sequestering cytoplasmic DNA and preventing its being bound by AIM2. {ECO:0000269PubMed:16670293, ECO:0000269PubMed:19131592, ECO:0000269PubMed:23567559}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:19131592}. Nucleus {ECO:0000269PubMed:19131592}. Note=Accumulates first in the cytoplasm, and is translocated to the nucleus after a delay, where it is primarily chromatin-associated.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003690	double-stranded DNA binding
GO:0005515	protein binding

Biological Process

GO:0006954	inflammatory response
GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0045087	innate immune response (InnateDB)
GO:0045824	negative regulation of innate immune response