Mus musculus Protein: Trim66
Summary
InnateDB Protein IDBP-206135.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Trim66
Protein Name tripartite motif-containing 66
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000033339
InnateDB Gene IDBG-206133 (Trim66)
Protein Structure
UniProt Annotation
Function May function as transcription repressor; The repressive effects are mediated, at least in part, by recruitment of deacetylase activity. May play a role as negative regulator of postmeiotic genes acting through CBX3 complex formation and centromere association. {ECO:0000269PubMed:15322135}.
Subcellular Localization Nucleus {ECO:0000269PubMed:15322135}. Note=Forms discrete foci within the centromeric chromocenter and surrounding nucleoplasm.
Disease Associations
Tissue Specificity Predominant in testis, specifically in elongating spermatids. {ECO:0000269PubMed:15322135}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
Experimentally validated
Total 7 [view]
Protein-Protein 7 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003682 chromatin binding
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0042803 protein homodimerization activity
Biological Process
GO:0045892 negative regulation of transcription, DNA-templated
Cellular Component
GO:0005622 intracellular
GO:0005634 nucleus
GO:0010369 chromocenter
Protein Structure and Domains
PDB ID MGI:2152406
InterPro IPR000315 Zinc finger, B-box
IPR001487 Bromodomain
IPR001965 Zinc finger, PHD-type
IPR003649 B-box, C-terminal
IPR011011 Zinc finger, FYVE/PHD-type
IPR019787 Zinc finger, PHD-finger
PFAM PF00643
PF00439
PF00628
PRINTS PR00503
PIRSF
SMART SM00336
SM00297
SM00249
SM00502
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q924W6
PhosphoSite PhosphoSite-Q924W6
TrEMBL Q6A089
UniProt Splice Variant
Entrez Gene 330627
UniGene Mm.183528
RefSeq NP_862901
MGI ID
MGI Symbol Trim66
OMIM
CCDS CCDS40082
HPRD
IMGT
EMBL AC124457 AJ307670 AK172929 AY572455
GenPept AAS78677 BAD32207 CAC38114