Version 5.4
| Mus musculus Protein: Klhl21 | |||||||||
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| Summary | |||||||||
| InnateDB Protein | IDBP-206192.6 | ||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||
| Gene Symbol | Klhl21 | ||||||||
| Protein Name | kelch-like 21 (Drosophila) | ||||||||
| Synonyms | |||||||||
| Species | Mus musculus | ||||||||
| Ensembl Protein | ENSMUSP00000095380 | ||||||||
| InnateDB Gene | IDBG-206190 (Klhl21) | ||||||||
| Protein Structure |
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| UniProt Annotation | |||||||||
| Function | Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of AURKB. Ubiquitination of AURKB by BCR(KLHL21) E3 ubiquitin ligase complex may not lead to its degradation by the proteasome (By similarity). {ECO:0000250}. | ||||||||
| Subcellular Localization | Cytoplasm, cytoskeleton, spindle {ECO:0000250}. Note=Localizes to the spindle midzone and targets CUL3 to this region. {ECO:0000250}. | ||||||||
| Disease Associations | |||||||||
| Tissue Specificity | |||||||||
| Comments | |||||||||
| Interactions | |||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Protein Structure and Domains | |||||||||
| PDB ID | MGI:1919288 | ||||||||
| InterPro |
IPR000210
BTB/POZ-like IPR006652 Kelch repeat type 1 IPR011333 BTB/POZ fold IPR011498 Kelch repeat type 2 IPR011705 BTB/Kelch-associated IPR013069 BTB/POZ IPR017096 Kelch-like protein, gigaxonin type |
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| PFAM |
PF01344
PF07646 PF07707 PF00651 |
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| PRINTS | |||||||||
| PIRSF |
PIRSF037037
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| SMART |
SM00225
SM00612 SM00875 |
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| TIGRFAMs | |||||||||
| Post-translational Modifications | |||||||||
| Modification | |||||||||
| Cross-References | |||||||||
| SwissProt | Q3U410 | ||||||||
| PhosphoSite | PhosphoSite- | ||||||||
| TrEMBL | |||||||||
| UniProt Splice Variant | |||||||||
| Entrez Gene | 242785 | ||||||||
| UniGene | Mm.22306 | ||||||||
| RefSeq | NP_001028524 | ||||||||
| MGI ID | |||||||||
| MGI Symbol | Klhl21 | ||||||||
| OMIM | |||||||||
| CCDS | CCDS18983 | ||||||||
| HPRD | |||||||||
| IMGT | |||||||||
| EMBL | AK154493 AK158141 AL611927 BC141158 BC141159 CH466594 | ||||||||
| GenPept | AAI41159 AAI41160 BAE32625 BAE34380 CAM24575 EDL14916 | ||||||||