Mus musculus Protein: Nol9
Summary
InnateDB Protein IDBP-206258.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Nol9
Protein Name nucleolar protein 9
Synonyms 4632412I24Rik; 6030462G04Rik; AI449622; AW490720;
Species Mus musculus
Ensembl Protein ENSMUSP00000099486
InnateDB Gene IDBG-206256 (Nol9)
Protein Structure
UniProt Annotation
Function Polynucleotide 5'-kinase involved in rRNA processing. The kinase activity is required for the processing of the 32S precursor into 5.8S and 28S rRNAs, more specifically for the generation of the major 5.8S(S) form. In vitro, has both DNA and RNA 5'-kinase activities. Probably binds RNA (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus, nucleolus {ECO:0000250UniProtKB:Q5SY16}. Nucleus {ECO:0000269PubMed:22872859}. Note=Colocalizes with pre-60S rRNP particles. {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 7 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003723 RNA binding
GO:0005524 ATP binding
GO:0051731 polynucleotide 5'-hydroxyl-kinase activity
Biological Process
GO:0000460 maturation of 5.8S rRNA
GO:0016310 phosphorylation
Cellular Component
GO:0005575 cellular_component
GO:0005730 nucleolus
GO:0016020 membrane
Protein Structure and Domains
PDB ID MGI:1921285
InterPro IPR010655 Pre-mRNA cleavage complex II Clp1
IPR027417 P-loop containing nucleoside triphosphate hydrolase
IPR029007 MobB-type P-loop domain
PFAM PF06807
PF03205
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q3TZX8
PhosphoSite PhosphoSite-Q3TZX8
TrEMBL
UniProt Splice Variant
Entrez Gene 74035
UniGene Mm.275803
RefSeq NP_083003
MGI ID
MGI Symbol Nol9
OMIM
CCDS CCDS18986
HPRD
IMGT
EMBL AK014568 AK042581 AK046761 AK050948 AK157398 AL611927 BC024877 BC125432 BC132099 CH466594
GenPept AAH24877 AAI25433 AAI32100 BAB29433 BAC31300 BAC32857 BAC34472 BAE34079 CAM24579 CAM24580 EDL14922