InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Lars2

Summary

InnateDB Protein

IDBP-206266.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Lars2

Protein Name

leucyl-tRNA synthetase, mitochondrial

Synonyms

AI035546; Kiaa0028; LEURS;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000036710

InnateDB Gene

IDBG-206264 (Lars2)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Mitochondrion matrix {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	1 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0002161	aminoacyl-tRNA editing activity
GO:0004812	aminoacyl-tRNA ligase activity
GO:0004823	leucine-tRNA ligase activity
GO:0005524	ATP binding

Biological Process

GO:0006418	tRNA aminoacylation for protein translation
GO:0006429	leucyl-tRNA aminoacylation
GO:0006450	regulation of translational fidelity

Cellular Component

GO:0005739	mitochondrion
GO:0005759	mitochondrial matrix

Protein Structure and Domains

PDB ID

MGI:2142973

InterPro

IPR002300 Aminoacyl-tRNA synthetase, class Ia
IPR002302 Leucine-tRNA ligase
IPR009008 Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain
IPR009080 Aminoacyl-tRNA synthetase, class 1a, anticodon-binding
IPR013155 Valyl/Leucyl/Isoleucyl-tRNA synthetase, anticodon-binding
IPR015413 Methionyl/Leucyl tRNA synthetase

PFAM

PF00133
PF08264
PF09334

PRINTS

PR00985

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q8VDC0