InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Fmn2

Summary

InnateDB Protein

IDBP-206315.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Fmn2

Protein Name

formin 2

Synonyms

AU024104;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000030039

InnateDB Gene

IDBG-206311 (Fmn2)

Protein Structure

UniProt Annotation

Function

Plays a role in responses to DNA damage, cellular stress and hypoxia by protecting CDKN1A against degradation, and thereby plays a role in stress-induced cell cycle arrest. Protects cells against apoptosis by protecting CDKN1A against degradation (By similarity). Actin-binding protein that is involved in actin cytoskeleton assembly and reorganization. Acts as an actin nucleation factor and promotes assembly of actin filaments together with SPIRE1 and SPIRE2. Involved in intracellular vesicle transport along actin fibers, providing a novel link between actin cytoskeleton dynamics and intracellular transport. Required for asymmetric spindle positioning, asymmetric oocyte division and polar body extrusion during female germ cell meiosis. {ECO:0000250, ECO:0000269PubMed:12447394, ECO:0000269PubMed:18848445, ECO:0000269PubMed:19062278, ECO:0000269PubMed:21620703, ECO:0000269PubMed:21983562}.

Subcellular Localization

Cytoplasm, cytoskeleton. Cytoplasm, cytosol. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cell cortex. Nucleus, nucleolus {ECO:0000250}. Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Note=Recruited to the membranes via its interaction with SPIRE1. Colocalizes with the actin cytoskeleton. Detected at the cleavage furrow during asymmetric oocyte division and polar body extrusion.

Disease Associations

Tissue Specificity

Detected in brain and in oocytes (at protein level). Expressed almost exclusively in the developing and mature central nervous system. Detected in oocytes. {ECO:0000269PubMed:12447394, ECO:0000269PubMed:19062278}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003779	actin binding

Biological Process

GO:0006974	cellular response to DNA damage stimulus
GO:0007275	multicellular organismal development
GO:0015031	protein transport
GO:0016192	vesicle-mediated transport
GO:0016344	meiotic chromosome movement towards spindle pole
GO:0040038	polar body extrusion after meiotic divisions
GO:0042177	negative regulation of protein catabolic process
GO:0043066	negative regulation of apoptotic process
GO:0045010	actin nucleation
GO:0046907	intracellular transport
GO:0048477	oogenesis
GO:0051017	actin filament bundle assembly
GO:0051295	establishment of meiotic spindle localization
GO:0051758	homologous chromosome movement towards spindle pole involved in homologous chromosome segregation
GO:0070649	formin-nucleated actin cable assembly
GO:0071456	cellular response to hypoxia

Cellular Component

GO:0005730	nucleolus
GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0005819	spindle
GO:0005829	cytosol
GO:0005884	actin filament
GO:0005886	plasma membrane
GO:0005902	microvillus
GO:0005938	cell cortex
GO:0015629	actin cytoskeleton
GO:0030659	cytoplasmic vesicle membrane