InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Sacm1l

Summary

InnateDB Protein

IDBP-206326.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Sacm1l

Protein Name

SAC1 (suppressor of actin mutations 1, homolog)-like (S. cerevisiae)

Synonyms

mKIAA0851; SAC1; Sac1p;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000026270

InnateDB Gene

IDBG-206324 (Sacm1l)

Protein Structure

UniProt Annotation

Function

Phosphoinositide phosphatase that hydrolyzes PtdIns(3)P and PtdIns(4)P. Has low activity towards PtdIns(3,5)P2 (By similarity). {ECO:0000250}.

Subcellular Localization

Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Detected in brain, lung, liver and kidney, and at lower levels in spleen and skeletal muscle. {ECO:0000269PubMed:11352561}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004438	phosphatidylinositol-3-phosphatase activity
GO:0005515	protein binding
GO:0016791	phosphatase activity
GO:0034593	phosphatidylinositol bisphosphate phosphatase activity
GO:0042578	phosphoric ester hydrolase activity
GO:0043812	phosphatidylinositol-4-phosphate phosphatase activity

Biological Process

GO:0008150	biological_process
GO:0046856	phosphatidylinositol dephosphorylation

Cellular Component

GO:0005789	endoplasmic reticulum membrane
GO:0005794	Golgi apparatus
GO:0030176	integral component of endoplasmic reticulum membrane
GO:0032281	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex