Version 5.4
Mus musculus Protein: Dennd5a
Summary
InnateDB Protein IDBP-206335.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Dennd5a
Protein Name DENN/MADD domain containing 5A
Synonyms 1500012B19Rik; AJ245569; AW496491; mKIAA1091; ORF37; Rab6ip1;
Species Mus musculus
Ensembl Protein ENSMUSP00000079295
InnateDB Gene IDBG-206333 (Dennd5a)
Protein Structure
UniProt Annotation
Function Guanine nucleotide exchange factor (GEF) which may activate RAB6A and RAB39A and/or RAB39B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form (By similarity). {ECO:0000250}.
Subcellular Localization Golgi apparatus membrane {ECO:0000269PubMed:19141279}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0017112 Rab guanyl-nucleotide exchange factor activity
GO:0017137 Rab GTPase binding
Biological Process
GO:0032313 regulation of Rab GTPase activity
GO:0032851 positive regulation of Rab GTPase activity
Cellular Component
GO:0000139 Golgi membrane
GO:0005794 Golgi apparatus
GO:0016020 membrane
Protein Structure and Domains
PDB ID MGI:1201681
InterPro IPR001024 PLAT/LH2 domain
IPR001194 DENN domain
IPR004012 RUN
IPR005112 dDENN domain
IPR005113 uDENN domain
IPR008976 Lipase/lipooxygenase, PLAT/LH2
PFAM PF01477
PF02141
PF02759
PF03455
PF03456
PRINTS
PIRSF
SMART SM00308
SM00799
SM00593
SM00801
SM00800
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q6PAL8
PhosphoSite PhosphoSite-Q6PAL8
TrEMBL
UniProt Splice Variant
Entrez Gene 19347
UniGene Mm.21904
RefSeq NP_067469
MGI ID 3CWZ
MGI Symbol Dennd5a
OMIM
CCDS CCDS21741
HPRD
IMGT
EMBL AJ245569 AK048609 BC022119 BC060230 L40894
GenPept AAA78787 AAH22119 AAH60230 BAC33389 CAB55599

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca