Version 5.4
Homo sapiens Protein: HSPB3
Summary
InnateDB Protein IDBP-20635.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HSPB3
Protein Name heat shock 27kDa protein 3
Synonyms DHMN2C; HMN2C; HSPL27;
Species Homo sapiens
Ensembl Protein ENSP00000303394
InnateDB Gene IDBG-20633 (HSPB3)
Protein Structure
UniProt Annotation
Function Inhibitor of actin polymerization.
Subcellular Localization Cytoplasm {ECO:0000269PubMed:19464326}. Nucleus {ECO:0000269PubMed:19464326}. Note=Translocates to nuclear foci during heat shock.
Disease Associations Neuronopathy, distal hereditary motor, 2C (HMN2C) [MIM:613376]: A neuromuscular disorder. Distal hereditary motor neuronopathies constitute a heterogeneous group of neuromuscular disorders caused by selective degeneration of motor neurons in the anterior horn of the spinal cord, without sensory deficit in the posterior horn. The overall clinical picture consists of a classical distal muscular atrophy syndrome in the legs without clinical sensory loss. The disease starts with weakness and wasting of distal muscles of the anterior tibial and peroneal compartments of the legs. Later on, weakness and atrophy may expand to the proximal muscles of the lower limbs and/or to the distal upper limbs. {ECO:0000269PubMed:20142617}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
Experimentally validated
Total 18 [view]
Protein-Protein 18 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0006986 response to unfolded protein
GO:0008219 cell death
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID
InterPro IPR001436 Alpha crystallin/Heat shock protein
IPR002068 Alpha crystallin/Hsp20 domain
IPR008978 HSP20-like chaperone
PFAM PF00011
PRINTS PR00299
PIRSF PIRSF036514
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q12988
PhosphoSite PhosphoSite-Q12988
TrEMBL Q6ICS9
UniProt Splice Variant
Entrez Gene 8988
UniGene Hs.732700
RefSeq NP_006299
HUGO HGNC:5248
OMIM 604624
CCDS CCDS3961
HPRD 06861
IMGT
EMBL AK314215 BC126272 BC132869 CH471123 CR450314 U15590 Y17782
GenPept AAD05360 AAI26273 AAI32870 BAG36889 CAA76848 CAG29310 EAW54893

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca