InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Grem2

Summary

InnateDB Protein

IDBP-206364.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Grem2

Protein Name

gremlin 2 homolog, cysteine knot superfamily (Xenopus laevis)

Synonyms

Gremlin2; Prdc;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000049640

InnateDB Gene

IDBG-206362 (Grem2)

Protein Structure

UniProt Annotation

Function

Cytokine that inhibits the activity of BMP2 and BMP4 in a dose-dependent manner, and thereby modulates signaling by BMP family members. Contributes to the regulation of embryonic morphogenesis via BMP family members. Antagonizes BMP4-induced suppression of progesterone production in granulosa cells. {ECO:0000269PubMed:15039429, ECO:0000269PubMed:23063586, ECO:0000269PubMed:23850456}.

Subcellular Localization

Secreted {ECO:0000305}.

Disease Associations

Tissue Specificity

Highly expressed in the ovary, followed by brain, spleen, colon, kidney and uterus. In ovary expressed in granulosa cells of selective early antral follicles. {ECO:0000269PubMed:15039429}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005125	cytokine activity
GO:0008201	heparin binding
GO:0036122	BMP binding
GO:0042803	protein homodimerization activity

Biological Process

GO:0010172	embryonic body morphogenesis
GO:0019221	cytokine-mediated signaling pathway
GO:0030514	negative regulation of BMP signaling pathway
GO:0038098	sequestering of BMP from receptor via BMP binding
GO:0048263	determination of dorsal identity
GO:0060300	regulation of cytokine activity