InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Slc6a20a

Summary

InnateDB Protein

IDBP-206404.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Slc6a20a

Protein Name

solute carrier family 6 (neurotransmitter transporter), member 20A

Synonyms

A730081N20Rik; AU022428; Xt3s1; Xtrp3s1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000047690

InnateDB Gene

IDBG-206402 (Slc6a20a)

Protein Structure

UniProt Annotation

Function

Mediates the calcium-dependent uptake of imino acids such as L-proline, N-methyl-L-proline and pipecolate as well as N- methylated amino acids. {ECO:0000269PubMed:15689184}.

Subcellular Localization

Apical cell membrane {ECO:0000269PubMed:16174864}; Multi-pass membrane protein {ECO:0000269PubMed:16174864}. Note=Located in the apical brush border membrane of kidney proximal tubule cells and in the apical membrane of enterocytes lining the intestinal villi. {ECO:0000269PubMed:16174864}.

Disease Associations

Tissue Specificity

Expressed in brain, kidney, small intestine, thymus, spleen and lung. In the brain, expressed in cerebellum, cortex and brain stem. Not detected in liver, muscle or heart. {ECO:0000269PubMed:15689184}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005328	neurotransmitter:sodium symporter activity
GO:0015171	amino acid transmembrane transporter activity

Biological Process

GO:0003333	amino acid transmembrane transport
GO:0006836	neurotransmitter transport
GO:0006865	amino acid transport
GO:0015816	glycine transport
GO:0015824	proline transport