InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: IGFBP7

Summary

InnateDB Protein

IDBP-20643.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

IGFBP7

Protein Name

insulin-like growth factor binding protein 7

Synonyms

AGM; FSTL2; IBP-7; IGFBP-7; IGFBP-7v; IGFBPRP1; MAC25; PSF; RAMSVPS; TAF;

Species

Homo sapiens

Ensembl Protein

ENSP00000295666

InnateDB Gene

IDBG-20639 (IGFBP7)

Protein Structure

UniProt Annotation

Function

Binds IGF-I and IGF-II with a relatively low affinity. Stimulates prostacyclin (PGI2) production. Stimulates cell adhesion. {ECO:0000269PubMed:8117260, ECO:0000269PubMed:8939990}.

Subcellular Localization

Secreted.

Disease Associations

Retinal arterial macroaneurysm with supravalvular pulmonic stenosis (RAMSVPS) [MIM:614224]: An autosomal recessive condition characterized by the bilateral appearance of 'beading' along the major retinal arterial trunks, with the subsequent formation of macroaneurysms. Affected individuals also have supravalvular pulmonic stenosis, often requiring surgical correction. {ECO:0000269PubMed:21835307}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.

Experimentally validated
Total	16 [view]
Protein-Protein	16 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0005520	insulin-like growth factor binding

Biological Process

GO:0001558	regulation of cell growth
GO:0007155	cell adhesion
GO:0007566	embryo implantation
GO:0008285	negative regulation of cell proliferation
GO:0009408	response to heat
GO:0014070	response to organic cyclic compound
GO:0032526	response to retinoic acid
GO:0032870	cellular response to hormone stimulus
GO:0048839	inner ear development
GO:0050810	regulation of steroid biosynthetic process
GO:0051414	response to cortisol

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0031012	extracellular matrix
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR000867 Insulin-like growth factor-binding protein, IGFBP
IPR002350 Kazal domain
IPR003599 Immunoglobulin subtype
IPR007110 Immunoglobulin-like domain
IPR011390 Insulin-like growth factor binding protein-related protein (IGFBP-rP), MAC25
IPR013098 Immunoglobulin I-set

PFAM

PF00219
PF00050
PF07648
PF07679

PRINTS

PIRSF

PIRSF018239

SMART

SM00121
SM00280
SM00409

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt