InnateDB Protein
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IDBP-206445.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Sun1
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Protein Name
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Sad1 and UNC84 domain containing 1
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Synonyms
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4632417G13Rik; 5730434D03Rik; mKIAA0810; Unc84a;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000077756
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InnateDB Gene
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IDBG-206439 (Sun1)
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Protein Structure
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Function |
Component of SUN-protein-containing multivariate complexes also called LINC complexes which link the nucleoskeleton and cytoskeleton by providing versatile outer nuclear membrane attachment sites for cytoskeletal filaments. Required for interkinetic nuclear migration (INM) and essential for nucleokinesis and centrosome-nucleus coupling during radial neuronal migration in the cerebral cortex and during glial migration. Anchors chromosome movement in the prophase of meiosis and is involved in selective gene expression of coding and non- coding RNAs needed for gametogenesis. Required for telomere attachment to nuclear envelope and gametogenesis. Helps to define the distribution of nuclear pore complexes (NPCs). Required for efficient localization of SYNE4 in the nuclear envelope. {ECO:0000269PubMed:16380439, ECO:0000269PubMed:17543860, ECO:0000269PubMed:19211677, ECO:0000269PubMed:19509342, ECO:0000269PubMed:19874786, ECO:0000269PubMed:23348741}.
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Subcellular Localization |
Nucleus inner membrane {ECO:0000269PubMed:11593002, ECO:0000269PubMed:12036294, ECO:0000269PubMed:16380439, ECO:0000269PubMed:16648470, ECO:0000269PubMed:17132086, ECO:0000269PubMed:17724119, ECO:0000269PubMed:18845190, ECO:0000269PubMed:19841137, ECO:0000269PubMed:19843581, ECO:0000269PubMed:19874786, ECO:0000269PubMed:23348741}; Single-pass type II membrane protein {ECO:0000269PubMed:11593002, ECO:0000269PubMed:12036294, ECO:0000269PubMed:16380439, ECO:0000269PubMed:16648470, ECO:0000269PubMed:17132086, ECO:0000269PubMed:17724119, ECO:0000269PubMed:18845190, ECO:0000269PubMed:19841137, ECO:0000269PubMed:19843581, ECO:0000269PubMed:19874786, ECO:0000269PubMed:23348741}.
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Disease Associations |
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Tissue Specificity |
Widely expressed. Expressed in cochlear outer hair cells (at protein level). {ECO:0000269PubMed:12036294, ECO:0000269PubMed:16380439, ECO:0000269PubMed:17132086, ECO:0000269PubMed:23348741}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated |
Total |
14
[view]
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Protein-Protein |
14
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
3 [view]
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Molecular Function |
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Biological Process |
GO:0006998
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nuclear envelope organization
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GO:0090286
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cytoskeletal anchoring at nuclear membrane
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GO:0090292
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nuclear matrix anchoring at nuclear membrane
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Cellular Component |
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PDB ID |
MGI:1924303
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InterPro |
IPR012919
Sad1/UNC-like, C-terminal
IPR018539
SUN domain-containing protein 1
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PFAM |
PF07738
PF09387
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q9D666
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PhosphoSite |
PhosphoSite-Q9D666
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TrEMBL |
E9LV91
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UniProt Splice Variant |
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Entrez Gene |
77053
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UniGene |
Mm.490889
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RefSeq |
NP_001243045
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MGI ID |
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MGI Symbol |
Sun1
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OMIM |
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CCDS |
CCDS57396
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HPRD |
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IMGT |
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EMBL |
AC125065
AF343752
AK014585
AK036187
AK160281
AK167686
AY682989
BC030330
BC047928
BC048156
HQ141867
HQ141868
HQ141869
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GenPept |
AAH30330
AAH47928
AAH48156
AAK13526
AAT90501
ADW08719
ADW08720
ADW08721
BAB29445
BAC29339
BAE35723
BAE39733
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