Version 5.4
Mus musculus Protein: Get4
Summary
InnateDB Protein IDBP-206495.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Get4
Protein Name golgi to ER traffic protein 4 homolog (S. cerevisiae)
Synonyms 1110007L15Rik; AW412535; Cee;
Species Mus musculus
Ensembl Protein ENSMUSP00000026976
InnateDB Gene IDBG-206493 (Get4)
Protein Structure
UniProt Annotation
Function Component of the BAT3 complex, a multiprotein complex involved in the post-translational delivery of tail-anchored (TA) membrane proteins to the endoplasmic reticulum membrane. TA membrane proteins, also named type II transmembrane proteins, contain a single C-terminal transmembrane region. The complex acts by facilitating TA proteins capture by ASNA1/TRC40: it is recruited to ribosomes synthesizing membrane proteins, interacts with the transmembrane region of newly released TA proteins, and transfers them to ASNA1/TRC40 for targeting (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm, cytosol {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 25 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 25 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
Biological Process
GO:0006810 transport
GO:0071816 tail-anchored membrane protein insertion into ER membrane
Cellular Component
GO:0005829 cytosol
GO:0071818 BAT3 complex
Protein Structure and Domains
PDB ID MGI:1914854
InterPro IPR007317 Uncharacterised protein family UPF0363
PFAM PF04190
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9D1H7
PhosphoSite PhosphoSite-Q9D1H7
TrEMBL
UniProt Splice Variant
Entrez Gene 67604
UniGene Mm.407966
RefSeq NP_080545
MGI ID
MGI Symbol Get4
OMIM
CCDS CCDS19805
HPRD
IMGT
EMBL AK003551 BC019557
GenPept AAH19557 BAB22851

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca