Version 5.4
Mus musculus Protein: Swap70
Summary
InnateDB Protein IDBP-206507.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Swap70
Protein Name SWA-70 protein
Synonyms 70kDa; AV235546;
Species Mus musculus
Ensembl Protein ENSMUSP00000033325
InnateDB Gene IDBG-206505 (Swap70)
Protein Structure
UniProt Annotation
Function Phosphatidylinositol 3,4,5-trisphosphate-dependent guanine nucleotide exchange factor (GEF) which, independently of RAS, transduces signals from tyrosine kinase receptors to RAC. It also mediates signaling of membrane ruffling. Regulates the actin cytoskeleton as an effector or adapter protein in response to agonist stimulated phosphatidylinositol (3,4)-bisphosphate production and cell protrusion (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm {ECO:0000250}. Cell membrane {ECO:0000250}. Nucleus {ECO:0000250}. Cell projection, lamellipodium {ECO:0000250}. Note=In resting B-cells it is localized mainly in the cytoplasm and upon cell activation it is recruited to the plasma membrane and then translocates to the nucleus. In activated, class-switching B-cells it is associated with membrane IgG but not IgM. Localized to loose actin filament arrays located behind actively extending lamellipodia (By similarity). {ECO:0000250}.
Disease Associations
Tissue Specificity Spleen. Expressed only in B-cells that have been induced to switch to various Ig isotypes. {ECO:0000269PubMed:10382743, ECO:0000269PubMed:9642267}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0005515 protein binding
GO:0005524 ATP binding
Biological Process
GO:0016444 somatic cell DNA recombination
GO:0045190 isotype switching
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0030027 lamellipodium
Protein Structure and Domains
PDB ID MGI:1298390
InterPro IPR001849 Pleckstrin homology domain
PFAM PF00169
PRINTS
PIRSF
SMART SM00233
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q6A028
PhosphoSite PhosphoSite-Q6A028
TrEMBL
UniProt Splice Variant
Entrez Gene 20947
UniGene Mm.334144
RefSeq NP_033328
MGI ID
MGI Symbol Swap70
OMIM
CCDS CCDS21744
HPRD
IMGT
EMBL AF053974 AK146773 AK150621 AK163357 AK172990 BC065136
GenPept AAC40155 AAH65136 BAD32268 BAE27422 BAE29711 BAE37316

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca