Version 5.4
Mus musculus Protein: Hes2
Summary
InnateDB Protein IDBP-206516.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Hes2
Protein Name hairy and enhancer of split 2 (Drosophila)
Synonyms HES-2;
Species Mus musculus
Ensembl Protein ENSMUSP00000030782
InnateDB Gene IDBG-206514 (Hes2)
Protein Structure
UniProt Annotation
Function Transcriptional repressor of genes that require a bHLH protein for their transcription.
Subcellular Localization Nucleus.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003690 double-stranded DNA binding
GO:0008134 transcription factor binding
GO:0046983 protein dimerization activity
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0045892 negative regulation of transcription, DNA-templated
Cellular Component
GO:0005634 nucleus
Protein Structure and Domains
PDB ID MGI:1098624
InterPro IPR003650 Orange
IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
IPR018352 Orange subgroup
PFAM PF07527
PF00010
PRINTS
PIRSF
SMART SM00353
SM00511
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O54792
PhosphoSite PhosphoSite-O54792
TrEMBL
UniProt Splice Variant
Entrez Gene 15206
UniGene Mm.57038
RefSeq NP_032262
MGI ID
MGI Symbol Hes2
OMIM
CCDS CCDS18995
HPRD
IMGT
EMBL AB009967 AK053792 AL772240 BC138112 CH466594
GenPept AAI38113 BAA24091 BAC35525 CAM19694 EDL14928

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca