InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Acot7

Summary

InnateDB Protein

IDBP-206535.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Acot7

Protein Name

acyl-CoA thioesterase 7

Synonyms

2410041A17Rik; Ach1; Act; Bach; Cte-II; CTE-IIa; Lach1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000074827

InnateDB Gene

IDBG-206533 (Acot7)

Protein Structure

UniProt Annotation

Function

Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. May play an important physiological function in brain. May play a regulatory role by modulating the cellular levels of fatty acyl- CoA ligands for certain transcription factors as well as the substrates for fatty acid metabolizing enzymes, contributing to lipid homeostasis. Has broad specificity, active towards fatty acyl-CoAs with chain-lengths of C8-C18. Has a maximal activity toward palmitoyl-CoA. {ECO:0000269PubMed:11834298}.

Subcellular Localization

Isoform A: Cytoplasm.Isoform D: Cytoplasm.

Disease Associations

Tissue Specificity

Widely expressed with highest levels in brain. High levels also found in thymus, large intestine and testis. Negligible in muscle and adipose tissue. In the central and peripheral nervous systems, displays a predominantly neuronal localization with highest expression in cell bodies and neurites. {ECO:0000269PubMed:11834298}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000062	fatty-acyl-CoA binding
GO:0005515	protein binding
GO:0016290	palmitoyl-CoA hydrolase activity
GO:0036042	long-chain fatty acyl-CoA binding
GO:0042803	protein homodimerization activity
GO:0047617	acyl-CoA hydrolase activity

Biological Process

GO:0009062	fatty acid catabolic process
GO:0015937	coenzyme A biosynthetic process
GO:0036114	medium-chain fatty-acyl-CoA catabolic process
GO:0036116	long-chain fatty-acyl-CoA catabolic process
GO:0051792	medium-chain fatty acid biosynthetic process
GO:1900535	palmitic acid biosynthetic process