Version 5.4
Mus musculus Protein: Acot7
Summary
InnateDB Protein IDBP-206537.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Acot7
Protein Name acyl-CoA thioesterase 7
Synonyms 2410041A17Rik; Ach1; Act; Bach; Cte-II; CTE-IIa; Lach1;
Species Mus musculus
Ensembl Protein ENSMUSP00000030779
InnateDB Gene IDBG-206533 (Acot7)
Protein Structure
UniProt Annotation
Function Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. May play an important physiological function in brain. May play a regulatory role by modulating the cellular levels of fatty acyl- CoA ligands for certain transcription factors as well as the substrates for fatty acid metabolizing enzymes, contributing to lipid homeostasis. Has broad specificity, active towards fatty acyl-CoAs with chain-lengths of C8-C18. Has a maximal activity toward palmitoyl-CoA. {ECO:0000269PubMed:11834298}.
Subcellular Localization Isoform A: Cytoplasm.Isoform D: Cytoplasm.
Disease Associations
Tissue Specificity Widely expressed with highest levels in brain. High levels also found in thymus, large intestine and testis. Negligible in muscle and adipose tissue. In the central and peripheral nervous systems, displays a predominantly neuronal localization with highest expression in cell bodies and neurites. {ECO:0000269PubMed:11834298}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 8 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0016290 palmitoyl-CoA hydrolase activity
Biological Process
GO:0009062 fatty acid catabolic process
Cellular Component
GO:0005829 cytosol
GO:0043005 neuron projection
GO:0044297 cell body
Protein Structure and Domains
PDB ID MGI:1917275
InterPro IPR006683 Thioesterase superfamily
IPR029069 HotDog domain
PFAM PF03061
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q91V12
PhosphoSite PhosphoSite-Q91V12
TrEMBL
UniProt Splice Variant
Entrez Gene 70025
UniGene Mm.296191
RefSeq XP_006539232
MGI ID 2V1O
MGI Symbol Acot7
OMIM
CCDS
HPRD
IMGT
EMBL AB049821 AB088411 AB088412 AB207243 AK152277 AL611985 AL671869 AL772240 BC013507
GenPept AAH13507 BAB61731 BAC20217 BAC20218 BAD91166 BAE31092 CAM19695 CAM19696 CAM19698 CAM23900 CAM23901 CAM23903 CAM26444 CAM26445 CAM26446

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca