InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ccr3

Summary

InnateDB Protein

IDBP-206552.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ccr3

Protein Name

chemokine (C-C motif) receptor 3

Synonyms

CC-CKR3; CKR3; Cmkbr1l2; Cmkbr3;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000039107

InnateDB Gene

IDBG-206550 (Ccr3)

Protein Structure

UniProt Annotation

Function

Receptor for a C-C type chemokine. Binds to eotaxin, MCP-3, MCP-4 and RANTES and subsequently transduces a signal by increasing the intracellular calcium ions level.

Subcellular Localization

Cell membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Detected in skeletal muscle and in trace amounts in leukocytes.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	7 [view]
Protein-Protein	7 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004930	G-protein coupled receptor activity
GO:0005515	protein binding
GO:0016493	C-C chemokine receptor activity

Biological Process

GO:0001938	positive regulation of endothelial cell proliferation
GO:0006935	chemotaxis
GO:0006954	inflammatory response
GO:0007186	G-protein coupled receptor signaling pathway
GO:0045087	innate immune response (InnateDB)
GO:0045766	positive regulation of angiogenesis
GO:0070098	chemokine-mediated signaling pathway

Cellular Component

GO:0005886	plasma membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

MGI:104616

InterPro

IPR000276 G protein-coupled receptor, rhodopsin-like
IPR000355 Chemokine receptor family
IPR000611 Neuropeptide Y receptor family
IPR002236 CC chemokine receptor 1
IPR002238 CC chemokine receptor 3
IPR017452 GPCR, rhodopsin-like, 7TM
IPR019424 7TM GPCR, olfactory receptor/chemoreceptor Srsx

PFAM

PF00001
PF10320

PRINTS

PR00237
PR00657
PR01012
PR01106
PR01108

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P51678